Table 3 Primary and secondary outcomes by study visit
| Â | Baseline | 3Â months | 6Â months | |||
|---|---|---|---|---|---|---|
|  | PAI (N = 13) | HLI (N = 7) | PAI (N = 10) | HLI (N = 7) | PAI (N = 13) | HLI (N = 5) |
VO2 peak (ml/kg/min) | ||||||
 Mean (SD) | 21.6 (4.59) | 17.2 (1.59) | 30.0 (6.26) | 24.6 (11.0) | 25.6 (9.00) | 28.5 (20.3) |
 Median (min, max) | 22.3 (15.5, 28.0) | 17.2 (15.6, 18.8) | 31.8 (21.5, 40.0) | 20.0 (17.4, 44.2) | 20.2 (18.5, 39.0) | 28.5 (14.2, 42.9) |
 Missing | 6 (46.2%) | 4 (57.1%) | 3 (30.0%) | 2 (28.6%) | 6 (46.2%) | 3 (60.0%) |
Six-minute walk distance | ||||||
 Mean (SD) | 502 (106) | 446 (14.1) | 549 (102) | 470 (75.4) | 522 (86.9) | 457 (118) |
 Median (min, max) | 543 (308, 595) | 443 (434, 465) | 581 (356, 659) | 482 (378, 555) | 537 (332, 630) | 495 (325, 553) |
 Missing | 4 (30.8%) | 3 (42.9%) | 0 (0%) | 1 (14.3%) | 3 (23.1%) | 2 (40.0%) |
LVEF rest | ||||||
 Mean (SD) | 57.2 (6.55) | 53.9 (8.74) | 52.4 (8.84) | 53.0 (12.0) | 49.8 (3.74) | 56.2 (15.0) |
 Median (min, max) | 56.6 (47.6, 65.3) | 57.1 (41.8, 62.1) | 51.5 (41.5, 64.5) | 56.8 (35.2, 68.0) | 50.7 (44.4, 54.6) | 61.0 (39.3, 68.3) |
 Missing | 5 (38.5%) | 2 (28.6%) | 2 (20.0%) | 1 (14.3%) | 5 (38.5%) | 2 (40.0%) |
LVEF exercise | ||||||
 Mean (SD) | 66.2 (5.08) | 63.6 (7.06) | 64.0 (7.64) | 64.5 (6.18) | 63.3 (4.01) | 69.6 (6.63) |
 Median (min, max) | 66.6 (60.1, 73.7) | 62.7 (57.0, 71.1) | 61.8 (55.4, 76.7) | 67.6 (54.2, 68.8) | 60.5 (60.0, 69.2) | 69.6 (64.9, 74.3) |
 Missing | 6 (46.2%) | 4 (57.1%) | 3 (30.0%) | 2 (28.6%) | 6 (46.2%) | 3 (60.0%) |
SV rest | ||||||
 Mean (SD) | 86.7 (10.8) | 85.6 (20.1) | 84.2 (25.5) | 87.8 (18.4) | 78.9 (19.2) | 88.4 (20.8) |
 Median (min, max) | 89.1 (64.4, 98.8) | 87.2 (60.3, 108) | 81.7 (58.4, 142) | 87.2 (62.2, 108) | 79.5 (60.5, 118) | 98.9 (64.4, 102) |
 Missing | 5 (38.5%) | 2 (28.6%) | 2 (20.0%) | 1 (14.3%) | 5 (38.5%) | 2 (40.0%) |
SV exercise | ||||||
 Mean (SD) | 104 (11.8) | 94.1 (33.5) | 102 (21.6) | 108 (19.7) | 95.2 (31.3) | 119 (3.30) |
 Median (min, max) | 101 (91.3, 121) | 89.7 (63.0, 130) | 100 (76.8, 143) | 113 (86.6, 136) | 85.4 (74.9, 164) | 119 (117, 122) |
 Missing | 6 (46.2%) | 4 (57.1%) | 3 (30.0%) | 2 (28.6%) | 6 (46.2%) | 3 (60.0%) |
CO rest | ||||||
 Mean (SD) | 6730 (1220) | 7630 (499) | 5700 (1440) | 7010 (2430) | 5850 (928) | 8000 (2080) |
 Median (min, max) | 6800 (5220, 8330) | 7350 (7320, 8200) | 5430 (4140, 8650) | 7040 (3790, 10,500) | 5880 (4050, 6930) | 8000 (6530, 9470) |
 Missing | 7 (53.8%) | 4 (57.1%) | 3 (30.0%) | 2 (28.6%) | 6 (46.2%) | 3 (60.0%) |
CO exercise | ||||||
 Mean (SD) | 15,200 (2530) | 14,100 (4740) | 16,700 (3570) | 16,600 (3750) | 16,000 (5510) | 17,700 (4060) |
 Median (min, max) | 16,200 (10,400, 18,100) | 12,200 (10,500, 19,400) | 17,400 (12,300, 22,500) | 15,400 (13,100, 22,000) | 13,500 (10,800, 27,200) | 17,700 (14,800, 20,600) |
 Missing | 6 (46.2%) | 4 (57.1%) | 3 (30.0%) | 2 (28.6%) | 6 (46.2%) | 3 (60.0%) |
FACIT-Fatigue | ||||||
 Mean (SD) | 34.4 (10.3) | 34.3 (10.3) | 42.0 (7.48) | 32.4 (8.52) | 36.4 (10.5) | 33.5 (2.38) |
 Median (min, max) | 30.3 (16.0, 48.0) | 37.0 (16.0, 43.0) | 44.0 (25.0, 49.0) | 30.0 (22.0, 46.0) | 39.0 (18.0, 51.0) | 32.5 (32.0, 37.0) |
 Missing | 2 (15.4%) | 1 (14.3%) | 0 (0%) | 0 (0%) | 2 (15.4%) | 1 (20.0%) |
FACT-General | ||||||
 Mean (SD) | 85.6 (14.3) | 78.9 (15.8) | 89.6 (9.93) | 76.6 (13.4) | 81.8 (17.7) | 73.3 (9.45) |
 Median (min, max) | 89.5 (53.7, 100) | 84.0 (52.0, 94.0) | 90.0 (74.0, 107) | 78.0 (60.0, 95.0) | 89.7 (37.2, 99.8) | 70.0 (66.0, 84.0) |
 Missing | 1 (7.7%) | 1 (14.3%) | 3 (30.0%) | 2 (28.6%) | 2 (15.4%) | 2 (40.0%) |
FACT-Lymphoma | ||||||
 Mean (SD) | 132 (23.2) | 114 (30.8) | 138 (15.8) | 112 (19.3) | 126 (25.6) | 116 (13.2) |
 Median (min, max) | 138 (76.7, 155) | 122 (62.0, 146) | 136 (118, 166) | 114 (92.0, 129) | 133 (59.2, 151) | 111 (106, 131) |
 Missing | 1 (7.7%) | 1 (14.3%) | 3 (30.0%) | 3 (42.9%) | 2 (15.4%) | 2 (40.0%) |
MVPA/week (mins) | ||||||
 Mean (SD) | 116 (34.1) | 128 (86.4) | 149 (41.3) | 192 (85.9) | 103 (47.1) | 127 (66.8) |
 Median (min, max) | 112 (66.8, 170) | 136 (15.3, 226) | 139 (78.1, 215) | 213 (73.2, 267) | 114 (20.8, 193) | 122 (54.3, 212) |
 Missing | 1 (7.7%) | 3 (42.9%) | 1 (10.0%) | 3 (42.9%) | 0 (0%) | 1 (20.0%) |
Steps/day | ||||||
 Mean (SD) | 7520 (2230) | 7710 (4420) | 9390 (2120) | 11,700 (4060) | 6820 (2870) | 8090 (3310) |
 Median (min, max) | 7310 (4440, 12,900) | 8840 (1760, 11,400) | 9610 (5270, 12,200) | 12,900 (5920, 15,100) | 7140 (1270, 12,900) | 7620 (4570, 12,500) |
 Missing | 1 (7.7%) | 3 (42.9%) | 1 (10.0%) | 3 (42.9%) | 0 (0%) | 1 (20.0%) |
Self-efficacy for walking | ||||||
 Mean (SD) | 5.92 (3.70) | 2.44 (1.05) | 7.07 (3.23) | 2.98 (3.24) | 6.79 (2.58) | 4.04 (3.34) |
 Median (min, max) | 5.67 (0.667, 10.0) | 2.67 (1.17, 4.00) | 8.33 (0.167, 10.0) | 2.33 (0.167, 9.83) | 6.58 (2.83, 10.0) | 3.08 (1.17, 8.83) |
 Missing | 2 (15.4%) | 1 (14.3%) | 0 (0%) | 0 (0%) | 1 (7.7%) | 1 (20.0%) |
Verbal fluency (COWAT) | ||||||
 Mean (SD) | 43.6 (9.29) | 43.7 (12.9) | 46.4 (9.02) | 41.7 (11.6) | 42.7 (6.45) | 48.3 (17.2) |
 Median (min, max) | 43.5 (24.0, 54.0) | 43.5 (30.0, 65.0) | 47.0 (32.0, 58.0) | 40.0 (31.0, 54.0) | 42.0 (34.0, 53.0) | 54.0 (29.0, 62.0) |
 Missing | 1 (7.7%) | 1 (14.3%) | 0 (0%) | 4 (57.1%) | 2 (15.4%) | 2 (40.0%) |